Validation protocol and quality control of the splitters
Set-up of the validation protocol and quality control of the splitters obtained from 3D printing in the CZFB facilities and co-designed by LEITAT. Dimensional, mechanical, emission and microbiological tests.
Protocol for cleaning and sterilizing the splitters
Set-up of the cleaning and sterilization protocol prior to the distribution of the splitters obtained by 3D printing and their effectiveness over time.
Validation protocol for hygienic masks
Set-up of the in-house protocol for the validation of masks manufactured specifically for the Covid-19 crisis, in collaboration with organizations such as AENOR.
Health & Biomedicine
Preparation of phage display libraries from PBMC of infected patients for the development of therapeutic antibodies.
Patients who have overcome SARS-Cov2 infection have developed immunity against the infection. The initiative promoted by Leitat-Salud in collaboration with other research centers (Taulí, CReSA) is based on cloning (duplicating) their immune system for the generation of antibody libraries and thus being able to select the best antibodies for therapy or diagnosis, in a period of less than 12 months.
Development of a rapid lateral flow diagnostic kit
Research in the development of a multiplex rapid diagnostic device for the determination of the immune response of patients against SARS-Cov2 combined with other infection-indicating proteins. This device will allow identifying patients at different stages of infection in just 15 minutes using a small blood sample. (in collaboration with the company Atrys)
Generation of monoclonal antibodies for diagnosis or therapy
Monoclonal antibodies are key elements for the therapy and diagnosis of most diseases. The Health Department has already started the process of generating antibodies to have these key tools for present and future needs against SARS-Cov2.
Animal model of pulmonary fibrosis
One of the side effects of those infected with COVID-19 is pulmonary fibrosis for which effective therapies are being sought. This development is being worked with the company Greenaltech.
In vitro model of pulmonary epithelial barrier (Leitat)
Development of a rapid lateral flow diagnostic system based on gold nanoparticles.
The objective of this initiative is to develop another type of fast, reliable, cheap and effective Point-of-care diagnostic kit to detect SARS-Cov-2 viruses by detecting viral proteins using conjugated gold nanoparticles. Research is being carried out together with Endor Nanotechnologies and other companies.
Health & Biomedicine – Energy & Engineering
Photonic diagnostic equipment for the quantification of viral RNA without PCR amplification
This technology has been developed within the framework of the European project ATTRACT (H2020-INFRAINNOV-2017, https://bit.ly/3dBloqr). PHIL technology will revolutionize the rapid molecular diagnostics sector by reducing the specific detection limit of SARS-CoV-2 without the need for DNA amplification and with a testing time of less than 5 minutes.
This development is a re-orientation of an ongoing project (PHIL, Attractant call) in collaboration with IFAE. Parc Taulí has joined the proposal.
Energy & Engineering
Participation in the design and development of the LEITAT 1 emergency respirator model, manufactured using 3D printing, in collaboration with CZFB, HP, Hospital Parc Taulí and CST.
Participation in the design and development of the splitter model for 3D-printed respirators, in collaboration with CZFB and Hospital Vall d'Hebron
Proposal to use mobile robotics for non-medical intralogistics operations in hospitals to minimize the risk of human exposure. Looking for potential partners.
Applied Chemistry & Materials
New formulations with antiviral properties and with high durability for detergency and for treatment of domestic and hospital surfaces.
The main technological innovation of this project is based, on the one hand, on the development of broad-spectrum surface decontamination solutions that will focus not only on bacteria and fungi, but also on viruses (including the SARS-CoV-2 coronavirus), which will help to considerably reduce the concentration of microorganisms harmful to human health on common surfaces in both the domestic and hospital environment. On the other hand, highly durable solutions (of more than 24 hours) will be investigated so that the number of operations of cleaning personnel can be reduced, while reducing their own risk of microbiological contamination. Leitat has experience in preliminary studies of surface cleaners and antimicrobial surfaces for applications related to the domestic and aeronautical sectors, technical fabrics, drinking water and greywater networks, and household appliances.
Development of Nanofibres to improve filtering and protective capacity of face masks
The development of this project involves the incorporation of nanofibers into the filter layer that will provide an improvement in the filtering capabilities and efficiency of the face masks, as well as a longer life span or lower cost, in addition to providing them with biocidal and antiviral activity due to doping of the Nanofiber surface. Preliminary studies carried out at Leitat have shown that these filter materials can show FFP2-FFP3 filtration efficiencies.
Genomic sequencing of the virus
Through this technique we can characterize the virus genetics in depth to study its evolution, reconstruct the transmission chains or study the presence of characteristics related to the different degrees of severity that infected patients show.
Survival studies of the virus on different types of surfaces and tissues
Surfaces contaminated with the virus are a vehicle for the transmission of COVID-19 disease. The main objective of these studies is to determine for how long the virus infectivity is maintained on different types of surfaces and to study if the tissues (clothing, sanitary uniforms, etc.) can act as transmission vehicles. This is of particular interest in the hospital setting, where hundreds of patients are being cared for and treated every day. (A development of LEITAT + CRESA * + Clinical partner)
Sanitation technologies for the elimination of the COVID19 virus in air and on different surfaces
Application of technologies such as UV, Plasma, Ozone, electrochemical technology, among others.